Activation of ventral tegmental area neurotensin Receptor-1 neurons promotes weight loss
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چکیده
منابع مشابه
Neurotensin inhibits both dopamine and GABA mediated inhibition of ventral tegmental 1 area dopamine neurons
26 Dopamine is an essential neurotransmitter that plays an important role in a number of 27 different physiological processes and disorders. There is substantial evidence that the 28 neuropeptide neurotensin interacts with the mesolimbic dopamine system and can regulate 29 dopamine neuron activity. In these studies we have used whole-cell patch clamp 30 electrophysiology in brain slices from mi...
متن کاملNeurotensin inhibits both dopamine- and GABA-mediated inhibition of ventral tegmental area dopamine neurons.
Dopamine is an essential neurotransmitter that plays an important role in a number of different physiological processes and disorders. There is substantial evidence that the neuropeptide neurotensin interacts with the mesolimbic dopamine system and can regulate dopamine neuron activity. In these studies we have used whole cell patch-clamp electrophysiology in brain slices from mice to examine h...
متن کاملIdentification of Neurotensin Receptor Expressing Cells in the Ventral Tegmental Area across the Lifespan
Neurotensin (Nts) promotes activation of dopamine (DA) neurons in the ventral tegmental area (VTA) via incompletely understood mechanisms. Nts can signal via the G protein-coupled Nts receptors 1 and 2 (NtsR1 and NtsR2), but the lack of methods to detect NtsR1- and NtsR2-expressing cells has limited mechanistic understanding of Nts action. To overcome this challenge, we generated dual recombina...
متن کاملThe effect of GABAB receptor activation within the ventral tegmental area on morphine-induced incentive sensitization in female rats
Repeated administration of morphine sensitizes animals to the stimulant and rewarding properties of the drug. It may also alter the expression and function of GABA receptors within the ventral tegmental area (VTA), a midbrain region that is implicated in morphine action. In the present study, the effect of activation of GABAB receptor subtypes within the VTA on morphine-induced incentive sensit...
متن کاملThe effect of GABAB receptor activation within the ventral tegmental area on morphine-induced incentive sensitization in female rats
Repeated administration of morphine sensitizes animals to the stimulant and rewarding properties of the drug. It may also alter the expression and function of GABA receptors within the ventral tegmental area (VTA), a midbrain region that is implicated in morphine action. In the present study, the effect of activation of GABAB receptor subtypes within the VTA on morphine-induced incentive sensit...
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ژورنال
عنوان ژورنال: Neuropharmacology
سال: 2021
ISSN: 0028-3908
DOI: 10.1016/j.neuropharm.2021.108639